Detecting bursts in the EEG of very and extremely premature infants using a multi-feature approach

https://doi.org/10.1016/j.medengphy.2017.04.003Get rights and content
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Highlights

  • Machine learning approach enables accurate detection of bursts in preterm EEG.

  • Features of amplitude and spectral shape capture discriminating information.

  • Improves reliability of estimates of inter-burst intervals.

Abstract

Aim: To develop a method that segments preterm EEG into bursts and inter-bursts by extracting and combining multiple EEG features. Methods: Two EEG experts annotated bursts in individual EEG channels for 36 preterm infants with gestational age < 30 weeks. The feature set included spectral, amplitude, and frequency-weighted energy features. Using a consensus annotation, feature selection removed redundant features and a support vector machine combined features. Area under the receiver operator characteristic (AUC) and Cohen’s kappa (κ) evaluated performance within a cross-validation procedure. Results: The proposed channel-independent method improves AUC by 4–5% over existing methods (p < 0.001, n=36), with median (95% confidence interval) AUC of 0.989 (0.973–0.997) and sensitivity–specificity of 95.8–94.4%. Agreement rates between the detector and experts’ annotations, κ=0.72 (0.36–0.83) and κ=0.65 (0.32–0.81), are comparable to inter-rater agreement, κ=0.60 (0.21–0.74). Conclusions: Automating the visual identification of bursts in preterm EEG is achievable with a high level of accuracy. Multiple features, combined using a data-driven approach, improves on existing single-feature methods.

Keywords

Burst detection
Electroencephalography
Preterm infant
Feature extraction
Spectral analysis
Support vector machine
Inter-burst interval

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Present address: BaBa Centre, University of Helsinki, Finland