Medical Engineering & Physics
Volume 32, Issue 9 , Pages 1074-1079 , November 2010

Acoustic and temporal analysis of speech: A potential biomarker for schizophrenia

  • Viliam Rapcan

      Affiliations

    • Trinity Centre for Bioengineering, Trinity College Dublin, Dublin 2, Ireland
    • Corresponding Author InformationCorresponding author. Tel.: +353 18964214; fax: +353 16795554.
  • ,
  • Shona D’Arcy

      Affiliations

    • Trinity Centre for Bioengineering, Trinity College Dublin, Dublin 2, Ireland
  • ,
  • Sherlyn Yeap

      Affiliations

    • Our Lady's Hospital, Navan, Ireland
  • ,
  • Natasha Afzal

      Affiliations

    • Fraser Health Care, Vancouver, Canada
  • ,
  • Jogin Thakore

      Affiliations

    • The Cognitive Neurophysiology Laboratory, St. Vincent's Hospital, Fairview, Dublin, Ireland
  • ,
  • Richard B. Reilly

      Affiliations

    • Trinity Centre for Bioengineering, Trinity College Dublin, Dublin 2, Ireland
    • The Cognitive Neurophysiology Laboratory, St. Vincent's Hospital, Fairview, Dublin, Ireland
    • Trinity Institute of Neuroscience, Trinity College Dublin, Dublin 2, Ireland

Received 31 March 2010 ,Revised 19 July 2010 ,Accepted 20 July 2010.

References 

  1. Bleuler E . Dementia praecox, or the group of schizophrenias. Translated by J. Zinkin (1911). New York: International University Press; 1950;
  2. Peralta V, Manuel JC. Factor structure and clinical validity of competing models of positive symptoms in schizophrenia. Biol Psychiatry. 1998;44:107–114
  3. Roy MA, DeVriendt X. Positive and negative symptoms in schizophrenia: a current overview. Can J Psychiatry. 1994;39:407–414
  4. Crow TJ. Brain changes and negative symptoms in schizophrenia. Psychopathology. 1995;28:18–21
  5. Blanchard JJ, Mueser KT, Bellack AS. Anhedonia, positive and negative affect, and social functioning in schizophrenia. Schizophr Bull. 1998;24:413–424
  6. United States , Public Health Service , Office of the Surgeon General , Center for Mental Health Services , National Institute of Mental Health . Mental health: a report of the surgeon general. Rockville, MD/Pittsburgh, PA: Dept. of Health and Human Services, U.S. Public Health Service; 1999;
  7. Alpert M, Kotsaftis A, Pouget ER. At issue: speech fluency and schizophrenic negative signs. Schizophr Bull. 1997;23:171–177
  8. Alpert M. Prosody and lexical accuracy in flat affect schizophrenia. Psychiatry Res. 2000;97:107–118
  9. Docherty NM, Strauss ME, Dinzeo TJ, St-Hilaire A. The cognitive origins of specific types of schizophrenic speech disturbances. Am J Psychiatry. 2006;163:2111–2118
  10. Wisniecki A, Cannizzaro M, Cohen H, Snyder P . Speech impairments in neurodegenerative diseases/psychiatric illnesses. Encyclopedia of language & linguistics. Elsevier; 2006;758–764
  11. Alpert M, Rosen A, Welkowitz J, Sobin C, Borod JC. Vocal acoustic correlates of flat affect in schizophrenia. Similarity to Parkinson's disease and right hemisphere disease and contrast with depression. Br J Psychiatry Suppl. 1989;51–56
  12. Greden JF, Albala AA, Smokler IA, Gardner R, Carroll BJ. Speech pause time: a marker of psychomotor retardation among endogenous depressives. Biol Psychiatry. 1981;16:851–859
  13. Kring AM, Alpert M, Neale JM, Harvey PD. A multimethod, multichannel assessment of affective flattening in schizophrenia. Psychiatry Res. 1994;54:211–222
  14. Shenton M, Dickey C, Frumin M, McCarley R. A review of MRI findings in schizophrenia. Schizophr Res. 2001;49:1–52
  15. Harrison PJ, Lewis DA. Neuropathology of schizophrenia. In:  Steven R,  Hirsch DRW editor. Schizophrenia. 2nd ed.. 2007;p. 310–325
  16. Weinberger DR, Marenco S. Schizophrenia as a neurodevelopmental disorder. In:  Steven R,  Hirsch DRW editor. Schizophrenia. 2nd ed.. 2007;p. 326–348
  17. Rund BR. Is there a degenerative process going on in the brain of people with schizophrenia?. Front Hum Neurosci. 2009;3:36
  18. Palmer BW, Heaton RK, Paulsen JS, Kuck J, Braff D, Harris MJ, et al. Is it possible to be schizophrenic yet neuropsychologically normal?. Neuropsychology. 1997;11:437–446
  19. Rapoport JL, Giedd J, Kumra S, Jacobsen L, Smith A, Lee P, et al. Childhood-onset schizophrenia. Progressive ventricular change during adolescence. Arch Gen Psychiatry. 1997;54:897–903
  20. de Jong LW, van der Hiele K, Veer IM, Houwing JJ, Westendorp RGJ, Bollen ELEM, et al. Strongly reduced volumes of putamen and thalamus in Alzheimer's disease: an MRI study. Brain. 2008;131:3277–3285
  21. Ferrand CT. Speech science: an integrated approach to theory and clinical practice. Boston: Pearson/Allyn and Bacon; 2007;
  22. Rapoport JL. Progressive cortical change during adolescence in childhood-onset schizophrenia: a longitudinal magnetic resonance imaging study. Arch Gen Psychiatry. 1999;56:649–654
  23. American Psychiatric Association . Diagnostic and statistical manual of mental disorders. 4th ed.. Washington: American Psychiatric Association; 1994;
  24. Spitzer RL, Williams JB, Gibbon M, First MB. The Structured clinical interview for DSM-III-R (SCID). I. History, rationale, and description. Arch Gen Psychiatry. 1992;49:624–629
  25. Overall JE, Gorham DR. The brief psychiatric rating scale. Psychol Rep. 1962;10:799–812
  26. Andreasen NC. The scale for the assessment of negative symptoms (SANS). Iowa City: University of Iowa; 1983;
  27. Stassen HH, Albers M, Püschel J, Scharfetter C, Tewesmeier M, Woggon B. Speaking behavior and voice sound characteristics associated with negative schizophrenia. J Psychiatr Res. 1995;29:277–296
  28. Eisler FG. Psycholinguistics: experiments in spontaneous speech. London/New York: Academic Press; 1968;
  29. Deller JR, Proakis JG, Hansen JHL. Discrete-time processing of speech signals. Upper Saddle River, NJ: Prentice-Hall; 1993;
  30. Xiao-Dan M, Jengshyang P, Sheng-He S. Efficient algorithms for speech pitch estimation. In: Proceedings of the 2001 international symposium on intelligent multimedia, video and speech processing. 2001;p. 421–424
  31. Duda R, Hart P, Stork D. In:  Edition S editors. Pattern classification. Wiley-Interscience; 2000;
  32. Kohavi R. A study of cross-validation and bootstrap for accuracy estimation and model selection. In: Proceedings of the 14th international joint conference on Artificial intelligence, vol. 2. Montreal, Quebec, Canada. 1995;
  33. Zweig MH, Campbell G. Receiver-operating characteristic (ROC) plots: a fundamental evaluation tool in clinical medicine. Clin. Chem. 1993;39:561–577
  34. D’Arcy S, Rapcan V, Penard N, Morris M, Robertson I, Reilly R. Speech as a means of monitoring cognitive function of elderly speakers. In: Proceedings of the interspeech conference. Brisbane, Australia. 2008;
  35. Saykin AJ, Shtasel DL, Gur RE, Kester DB, Mozley LH, Stafiniak P, et al. Neuropsychological deficits in neuroleptic naive patients with first-episode schizophrenia. Arch Gen Psychiatry. 1994;51:124–131
  36. Stassen HH. Affective state and voice: the specific properties of overtone distributions. Methods Inf Med. 1991;30:44–52
  37. Moran RJ, Reilly RB, de Chazal P, Lacy PD. Telephony-based voice pathology assessment using automated speech analysis. IEEE Trans Biomed Eng. 2006;53:468–477
  38. Wormald RN, Moran RJ, Reilly RB, Lacy PD. Performance of an automated, remote system to detect vocal fold paralysis. Ann Otol Rhinol Laryngol. 2008;117:834–838

PII: S1350-4533(10)00165-7

doi: 10.1016/j.medengphy.2010.07.013

Medical Engineering & Physics
Volume 32, Issue 9 , Pages 1074-1079 , November 2010