« Previous
Next »
Medical Engineering & Physics
Volume 31, Issue 4
, Pages 420-427
, May 2009
Deformation simulation of cells seeded on a collagen-GAG scaffold in a flow perfusion bioreactor using a sequential 3D CFD-elastostatics model
References
- American Association of Orthopaedic Surgeons Report 2002.
- . Bone tissue engineering: hope vs hype. Biochem Biophys Res Commun. 2002;292:1–7
- Wintermantel E, Ha S-W. Medizintechnik mit biokompatiblen Werkstoffen und Verfahren, Springer Verlag. ISBN: 978-3540412618; 2002.
- . Formation of highly porous biodegradable scaffolds for tissue engineering. EJB Electron J Biotechnol. 2000;3(2):1–6
- . Synthesis and characterization of a model extracellular matrix that induces partial regeneration of adult mammalian skin. Proc Natl Acad Sci U S A. 1989;86:933–937
- . Influence of freezing rate on pore structure in freeze-dried collagen-GAG scaffolds. Biomaterials. 2004;25:1077–1086
- A collagen-glycosaminoglycan scaffold supports adult rat mesenchymal stem cell differentiation along osteogenic and chondrogenic routes. Tissue Eng. 2006;12(3):459–468
- . Organized skin structure is regenerated in vivo from collagen-GAG matrices seeded with autologous keratinocytes. J Invest Dermatol. 1998;110(6):908–916
- Fluid flow increases mineralized matrix deposition in 3D perfusion culture of marrow stromal osteoblasts in a dose-dependent manner. Proc Natl Acad Sci USA. 2002;99(20):12600–12605
- . Effects of media perfusion rate on cell seeded 3D bone constructs in vitro. Tissue Eng. 2003;9(6):1197–1203
- . Design and validation of a dynamic flow perfusion bioreactor for use with compliant tissue engineering scaffolds. J Biotechnol. 2008;133(4):490–496
- . Magnitudes of local stress and strain along bony surfaces predict the course and type of fracture healing. J Biomech. 1999;32:255–266
- . Mechanobiology of skeletal regeneration. Clin Orthop Related Res. 1988;355S:S41–S55
- . Biophysical stimuli on cells during tissue differentiation at implant interfaces. J Biomech. 1997;30(6):539–548
- . A comparison of strain and fluid shear stress in stimulating bone cell responses—a computational and experimental study. FASEB J. 2005;19(3):482–484
- . A model for the role of integrins in flow induced mechanotranduction in osteocytes. PNAS. 2007;104(40):15941
- . A model for the excitation of osteocytes by mechanical loading-induced bone fluid shear stresses. J Biomech. 1994;27:339
- . Induction of NO and prostaglandin E2 in osteoblasts by wall-shear stress but not mechanical strain. Am J Physiol Endocrinol Metab. 1997;273(4):E751–E758
- . Mechanical stimulation of MC3T3 osteoblastic cells in a bone tissue-engineering bioreactor enhances prostaglandin E2 release. Tissue Eng. 2005;11:1832–1839
- . Mechanical stimulation of osteoblasts using steady and dynamic fluid flow. Tissue Eng Part A. 2008;14(7):1213–1223
- . Role of cell location and morphology in the mechanical environment around meniscal cells. Acta Biomaterialia. 2006;2(5):483–492
- . 3-D computational modeling of media flow through scaffolds in a perfusion bioreactor. J Biomech. 2005;38(3):543–549
- . Modeling evaluation of the fluid-dynamic microenvironment in tissue-engineered constructs: a micro-CT based model. Biotechnol Bioeng. 2005;93(3):500–510
- . A finite element study of mechanical stimuli in scaffolds for bone tissue engineering. J Biomech. 2008;41:1005–1014
- McMahon L. The effect of cyclic tensile loading and growth factors on the chondrogenic differentiation of bone-marrow derived mesenchymal stem cells in a collagen-glycosaminoglycan scaffold, PhD thesis, Trinity College Dublin, 2007.
- . The effect of pore size on cell adhesion in collagen-GAG scaffolds. Biomaterials. 2005;26(4):433–441
- . Micromechanics of fibroblast contraction of a collagen-GAG matrix. Exp Cell Res. 2001;269:140
- . Cell deformation in cancer metastasis: a BioMEMS based approach. J Phys: Conference Ser. 2006;34:1143–1147
- Haugh MG, Jaasma MJ, O’Brien FJ. The effect of dehydrothermal treatment on the mechanical and structural properties of collagen-GAG scaffolds. J Biomed Mater Res A. 2008. [Epub ahead of print].
- . Mechanical characterization of collagen-glycosaminoglycan scaffolds. Acta biomaterialia. 2007;3(4):463–474
- http://www.opencfd.co.uk/openfoam/
- . A three-dimensional viscoelastic model for cell deformation with experimental verification. Biophys J. 2003;85:3336–3349
- . The application of a homogenous half-space model in the analysis of endothelial cell micropipette measurements. J Biomech Eng. 1998;110(3):190–199
- Effects of short-term recovery periods on fluid-induced signaling in osteoblastic cells. J Biomech. 2005;38:1909–1917
- . Principles of bone formation driven by biophysical forces in craniofacial surgery. Br J Oral Maxillofacial Surg. 2006;44:289–295
PII: S1350-4533(08)00205-1
doi: 10.1016/j.medengphy.2008.11.003
© 2008 IPEM. Published by Elsevier Inc. All rights reserved.
« Previous
Next »
Medical Engineering & Physics
Volume 31, Issue 4
, Pages 420-427
, May 2009
