Medical Engineering & Physics
Volume 31, Issue 5 , Pages 495-509 , June 2009

Hand-held based near-infrared optical imaging devices: A review

Received 9 April 2008 ,Revised 12 July 2008 ,Accepted 15 October 2008.

References 

  1. Fantini S, Walker SA, Franceschini MA, Kaschke M, Schlag PM, Moesta KT. Assessment of the size, position, and optical properties of breast tumors in vivo by noninvasive optical methods. Appl Opt. 1998;37:1982–1989
  2. Eppstein MJ, Hawrysz DJ, Godavarty A, Sevick-Muraca EM. Three-dimensional near-infrared fluorescence tomography with Bayesian methodologies for image reconstruction from sparse and noisy data sets. Proc Natl Acad Sci USA. 2002;99:9619–9624
  3. Milstein B, Stott JJ, Oh S, Boas DA, Millane RP, Bouman CA, et al. Fluorescence optical diffusion tomography using multiple-frequency data. J Opt Soc Am A. 2004;21(6):1035–1049
  4. Lee J, Sevick-Muraca EM. 3-D Fluorescence enhanced optical tomography using references frequency-domain photon migration measurements at emission and excitation measurements. J Opt Soc Am A. 2002;19:759–771
  5. Quaresima V, Matcher SJ, Ferrari M. Identification and quantification of intrinsic optical contrast for near-infrared mammography. Photochem Photobiol. 1998;67:4–14
  6. Li X, Culver J, Durduran T, Chance B, Yodh AG, Pattanayak DN. Diffraction tomography with diffuse-photon density waves: clinical studies and background subtraction. In Sevick-Muraca E, Izatt J, Ediger M, editors. Biomedical optical spectroscopy and diagnostics/therapeutic laser applications. Vol. 22 of OSA Trends in Optics and Photonics Series (Optical Society of America, 1998). Paper JTuA3.
  7. Ntziachristos V, Weissleder R. Experimental three-dimensional fluorescence reconstruction of diffuse media by use of a normalized Born approximation. Opt Lett. 2001;26:893–895
  8. Yang Y, Iftimia N, Xu Y, Jiang H. Frequency-domain fluorescent diffusion tomography of turbid media and in vivo tissues. In:  Chance B,  Alfano RR,  Tromberg BJ editor. Optical tomography and spectroscopy of tissue IV. Proc. Soc. Photo-Opt. Instrum. Eng. vol. 4250:2001;p. 537–545
  9. Ntziachristos V, Bremer C, Weissleder R. Fluorescence imaging with near-infrared light: new technological advances that enable in vivo molecular imaging. Eur Radiol. 2003;13:195–208
  10. Ntziachristos V, Weissleder R. Charge-coupled-device based scanner for tomography of fluorescent near-infrared probes in turbid media. Med Phys. 2002;29:803–809
  11. Ntziachristos V, Bremer C, Tung C, Weissleder R. Imaging cathepsin B up-regulation in HT-1080 tumor models using fluorescence-mediated molecular tomography (FMT). Acad Radiol. 2002;9(Suppl. 2):S323–S325
  12. Schulz RB, Ripoll J, Ntziachristos V. Noncontact optical tomography of turbid media. Opt Lett. 2003;28(18):1701–1703
  13. Ntziachristos V, Schellenberger EA, Ripoll J, Yessayan D, Graves E, Bogdanov A, et al. Visualization of antitumor treatment by means of fluorescence molecular tomography with an annexin V–Cy5.5 conjugate. Proc Natl Acad Sci USA. 2004;101(33):12294–12299
  14. Schulz RB, Ripoll J, Ntziachristos V. Experimental fluorescence tomography of tissues with noncontact measurements. IEEE Trans Med Imaging. 2004;23(4):492–500
  15. Bremer C, Ntziachristos V, Weitkamp B, Theilmeier G, Heindel W, Weissleder R. Optical imaging of spontaneous breast tumors using protease sensing ‘smart’ optical probes. Invest Radiol. 2005;40(6):321–327
  16. Colak SB, Papaioannou DG, t’Hooft GW, van der Mark MB, Schomberg H, Paasschens JCJ, et al. Tomographic image reconstruction from optical projections in light-diffusing media. Appl Opt. 1997;36:180–213
  17. Godavarty A, Thompson AB, Roy R, Eppstein MJ, Zhang C, Gurfinkel M, et al. Diagnostic imaging of breast cancer using fluorescence-enhanced optical tomography: phantom studies. J Biomed Opt. 2004;9(3):488–496[Special edition on Biomedical Optics and Women's Health]
  18. Godavarty A, Eppstein MJ, Zhang C, Theru S, Thompson AB, Gurfinkel M, et al. Fluorescence-enhanced optical imaging in large tissue volumes using a gain modulated ICCD camera. Phys Med Biol. 2003;48:1701–1720
  19. Godavarty A, Zhang C, Eppstein MJ, Sevick-Muraca EM. Fluorescence-enhanced optical imaging of large phantoms using single and simultaneous dual point illumination geometries. Med Phys. 2004;31:183–190
  20. Godavarty A, Sevick-Muraca EM, Eppstein MJ. Three-dimensional fluorescence lifetime tomography. Med Phys. 2005;32:992–1000
  21. Jayachandran B, Ge J, Regalado S, Godavarty A. Design and development of a hand-held optical probe toward fluorescence diagnostic imaging. J Biomed Opt. 2007;12(5):054014
  22. Zhu B, Eppstein MJ, Sevick-Muraca EM, Godavarty A. Noise pre-filtering techniques in fluorescence-enhanced optical tomography. Opt Express. 2007;15(18):11285–11300
  23. Zhu Q, Chen NG, Piao DQ, Guo PY, Ding XH. Design of near-infrared imaging probe with the assistance of ultrasound localization. Appl Opt. 2001;40(19):3288–3303
  24. Tromberg BJ. Optical scanning and breast cancer. Acad Radiol. 2005;12(8):923–924
  25. Pham TH, Coquoz O, Fishkin JB, Anderson E, Tromberg BJ. Broad bandwidth frequency domain instrument for quantitative tissue optical spectroscopy. Rev Sci Instrum. 2000;71(6):2500–2513
  26. Tromberg B, Coquoz O, Fishkin JB, Pham T, Anderson ER, Butler J, et al. Non-invasive measurements of breast tissue optical properties using frequency-domain photon migration. Philos Trans R Soc Lond B Biol Sci. 1997;352:661–668
  27. Lanning R, Tromberg . Non-invasive characterization of breast cancer using near infrared optical spectroscopy. UCI Undergraduate Res J II. 1999;2:43–49
  28. Tromberg BJ, Shah N, Lanning R, Cerussi A, Espinoza J, Pham T, et al. Noninvasive in vivo characterization of breast tumors using photon migration spectroscopy. Neoplasia. 2000;2(1–2):26–40
  29. Holboke MJ, Tromberg BJ, Li X, Shah N, Fishkin J, Kidney D, et al. Three-dimensional diffuse optical mammography with ultrasound localization in a human subject. J Biomed Opt. 2000;5(2):237–247
  30. Cerussi AE, Berger AJ, Bevilacqua F, Shah N, Jakubowski D, Butler J, et al. Sources of absorption and scattering contrast for near-infrared optical mammography. Acad Radiol. 2001;8:211–218
  31. Shah N, Cerussi A, Eker C, Espinoza J, Butler J, Fishkin J, et al. Noninvasive functional optical spectroscopy of human breast tissue. Proc Natl Acad Sci USA. 2001;98(8):4420–4425
  32. Shah N, Cerussi AE, Jakubowski D, Hsiang D, Butler J, Tromberg BJ. Spatial variations in optical and physiological properties of healthy breast tissue. J Biomed Opt. 2004;9(3):534–540
  33. Bevilacqua F, Berger AJ, Cerussi AE, Jakubowski D, Tromberg BJ. Broadband absorption spectroscopy in turbid media by combined frequency-domain and steady-state methods. Appl Opt. 2000;39(34):6498–6507
  34. Cerussi AE, Jakubowski D, Shah N, Bevilacqua F, Lanning R, Berger AJ, et al. Spectroscopy enhances the information content of optical mammography. J Biomed Opt. 2002;7(1):60–71
  35. Jakubowski DB, Cerussi AE, Bevilacqua F, Shah N, Hsiang D, Butler J, et al. Monitoring neoadjuvant chemotherapy in breast cancer using quantitative diffuse optical spectroscopy: a case study. J Biomed Opt. 2004;9(1):230–238
  36. Shah N, Gibbs J, Wolverton D, Cerussi A, Hylton N, Tromberg BJ. Combined diffuse optical spectroscopy and contrast-enhanced magnetic resonance imaging for monitoring breast cancer neoadjuvant chemotherapy: a case study. J Biomed Opt. 2005;10(5):051503
  37. Hsiang D, Shah N, Yu H, Su MY, Cerussi A, Butler J, et al. Coregistration of dynamic contrast enhanced MRI and broadband diffuse optical spectroscopy for characterizing breast cancer. Technol Cancer Res Treat. 2005;4(5):549–558
  38. Cerussi A, Shah N, Hsiang D, Durkin A, Butler J, Tromberg BJ. In vivo absorption, scattering, and physiologic properties of 58 malignant breast tumors determined by broadband diffuse optical spectroscopy. J Biomed Opt. 2006;11(4):044005
  39. Cerussi A, Hsiang D, Shah N, Mehta R, Durkin A, Butler J, et al. Predicting response to breast cancer neoadjuvant chemotherapy using diffuse optical spectroscopy. Proc Natl Acad Sci USA. 2007;104(10):4014–4019
  40. No KS, Chou PH. Mini-FDPM and heterodyne mini-FDPM: handheld non-invasive breast cancer detectors based on frequency-domain photon migration. IEEE Trans Circuits Syst—I: Regul Pap. 2005;52(December (12)):2672–2685
  41. No KS, Xie Q, Kwong R, Cerussi A, Tromberg BJ, Chou P. HBS: a handheld breast cancer detector based on frequency domain photon migration with full heterodyne. In: Proceedings of IEEE BioCAS, November 29–December 1. London: The British Library; 2006;
  42. No KS, Xie Q, Chou PH, Kwong R, Cerussi A, Tromberg BJ. In vivo breast cancer measurement with a handheld laser breast scanner. In: The 50th IEEE international Midwest symposium on circuits and systems (MWSCAS), August 5–8, Montreal Marriott Chateau Champlain Hotel. 2007;
  43. Chance B, Nioka S, Zhang J, Conant EF, Hwang E, Briest S, et al. Breast cancer detection based on incremental biochemical and physiological properties of breast cancers: a six-year, two-site study. Acad Radiol. 2005;12(8):925–933
  44. Nioka S, Chance B. NIR spectroscopic detection of breast cancer. Technol Cancer Res Treat. 2005;4(5):497–512
  45. Sao V, Pourrezaei K, Akin A, Ayaz H. Breast tumor imaging using NIR LED based handheld continuous-wave imager. In:  Reisman S,  Foulds R,  Mantilla B editor. Proceedings of the IEEE 29th annual NE bioengineering conference, March 22–23. 2003;p. 55–56
  46. Chance B, Zhao Z, Wen S, Chen Y. Simple ac circuit for breast cancer detection and object detection. Rev Sci Instrum. 2006;77:064301
  47. Liu Q, Luo Q, Chance B. 2D phased array fluorescence wireless localizer in breast cancer detection. In: IEEE/EMBS international summer school on medical devices and biosensors (ISSS-MD), June 26–July 2. 2004;p. 71–73
  48. Xu R, Qiang B, Mao J. Near infrared imaging of tissue heterogeneity: probe design and sensitivity analysis. In: IEEE Eng. in Med. and Biol. 27th annual conference, Shanghai, China September 1–4. 2005;
  49. Xu RX, Olsen JO, Povoski SP, Yee LD, Mao J. Localization and functional parameter reconstruction of suspicious breast lesions by near infrared/ultrasound dual mode imaging. In: IEEE Eng. in Med. and Biol. 27th annual conference, Shanghai, China September 1–4. 2005;
  50. Xu JRX, Qiang B, Mao JJ, Povoski SP. Development of a handheld near infrared imager for dynamic characterization of in vivo biological tissue systems. Appl Opt. 2007;46:7442–7451
  51. Choe R. Diffuse optical tomography and spectroscopy of breast cancer and fetal brain. PhD thesis. University of Pennsylvania; 2005.
  52. Durduran T, Choe R, Yu G, Zhou C, Tchou JC, Czerniecki BJ, et al. Diffuse optical measurement of blood flow in breast tumors. Opt Lett. 2005;30(21):2915–2917
  53. Liebert A, Wabnitz H, Steinbrink J, Moller M, Macdonald R, Rinneberg H, et al. Bed-side assessment of cerebral perfusion in stroke patients based on optical monitoring of a dye bolus by time-resolved diffuse reflectance. NeuroImage. 2005;24:426–435
  54. Sunar U, Quon H, Durduran T, Zhang J, Du J, Zhou C, et al. Noninvasive diffuse optical measurement of blood flow and blood oxygenation for monitoring radiation therapy in patients with head and neck tumors: a pilot study. J Biomed Opt. 2006;11(6):064021
  55. Zhu Q, Durduran T, Ntziachristos V, Holboke M, Yodh AG. Imager that combines near-infrared diffusive light and ultrasound. Opt Lett. 1999;24(15):1050–1052
  56. Guo P, Piao D, Zhu Q, Fikiet J. A combined 2-D ultrasound and NIR imaging system. In: Proceedings of the IEEE 26th annual NE bioengineering conference, April 8–9. 2000;p. 77–78
  57. Zhu Q, Chen NG, Guo P, Yan SK, Piao D. Combined ultrasound and near infrared diffusive light imaging. IEEE Symp Ultrasonics. 2000;1629–1632
  58. Chen NG, Guo P, Yan S, Piao D, Zhu Q. Simultaneous near-infrared diffusive light and ultrasound imaging. Appl Opt. 2001;40(34):6367–6380
  59. Zhu Q, Chen NG, Kurtzman SH. Imaging tumor angiogenesis by use of combined near-infrared diffusive light and ultrasound. Opt Lett. 2003;28(5):337–339
  60. Zhu Q, Huang M, Chen NG, Zarfos K, Jagjivan B, Kane M, et al. Ultrasound-guided optical tomographic imaging of malignant and benign breast lesions: initial clinical results of 19 cases. Neoplasia. 2003;5(5):379–388
  61. Chen NG, Huang M, Xia H, Piao D. Portable near-infrared diffusive light imager for breast cancer detection. J Biomed Opt. 2004;9(3):504–510
  62. Zhu Q, Cronin EB, Currier AA, Vine HS, Huang M, Chen NG, et al. Benign versus malignant breast masses: optical differentiation with US-guided optical imaging reconstruction. Radiology. 2005;237:57–66
  63. Zhu Q, Kurtzman SH, Hegde P, Tannenbaum S, Kane M, Huang M, et al. Utilizing optical tomography with ultrasound localization to image heterogeneous hemoglobin distribution in large breast cancers. Neoplasia. 2005;7(3):263–270
  64. Xu C, Zhu Q. Optimal probe design for dual-modality breast imaging. In:  Chance Britton,  Alfano Robert R,  Tromberg Bruce J,  Tamura Mamoru,  Sevick-Muraca Eva M editor. Proceedings of SPIE–optical tomography and spectroscopy of tissue VII, February 13, vol. 6434. 2007;p. 64340B
  65. Chance B, Leigh JS, Miyake H, Smith DS, Nioka S, Greenfeld R, et al. Comparison of time-resolved and -unresolved measurements of deoxyhemoglobin in brain. Proc Natl Acad Sci USA. 1988;85:4791–4975
  66. Doornbos RMP, Lang R, Aalders MC, Cross FW, Sterenborg HJCM. The determination of in vivo human tissue optical properties and absolute chromophore concentrations using spatially resolved steady-state diffuse reflectance spectroscopy. Phys Med Biol. 1999;44:967–981
  67. Arridge SR, Lionheart WRB. Nonuniqueness in diffusion-based optical tomography. Opt Lett. 1998;23:882–884
  68. Balgi G, Reynolds JS, Mayer RH, Cooley R, Sevick-Muraca EM. Measurements of multiply scattered light for on-line monitoring of changes in size distribution of cell-debris suspensions. Biotechnol Prog. 1999;15:1106–1114
  69. Schmitt JM, Knuttel A, Knutson JR. Interference of diffusive light waves. J Opt Soc Am A. 1992;9:1832–1843
  70. Knuttel A, Schmitt JM, Barnes R, Knutson JR. Spatial localization of absorbing bodies by interfering diffusive photon density waves. Appl Opt. 1993;32:381–389
  71. Knuttel A, Schmitt JM, Barnes R, Knutson JR. Acoustic-optic scanning and interfering photon density waves for precise localization of an absorbing (or fluorescent) body in a turbid medium. Rev Sci Instrum. 1993;64:638–644
  72. Chance B, Kang K, He L, Weng J, Sevick E. Highly sensitive object location in tissue models with linear in-phase and anti-phase multi-element optical arrays in one and two dimensions. Proc Natl Acad Sci USA. 1993;90:3423–3427
  73. Chen Y, Mu C, Intes X, Chance B. Adaptive calibration for object localization in turbid media with interfering diffuse photon density waves. Appl Opt. 2002;41:7325–7333
  74. Houston JP, Thompson AB, Gurfinkel M, Sevick-Muraca EM. Sensitivity and depth penetration of continuous wave versus frequency-domain photon migration near-infrared fluorescence contrast-enhanced imaging. Photochem Photobiol. 2003;77:420–430
  75. Delpy DT, Cope M. Quantification in tissue near-infrared spectroscopy. Philos Trans R Soc Lond B. 1997;352:649–659
  76. Ge J, Zhu B, Regalado S, Godavarty A. Three-dimensional fluorescence-enhanced optical tomography using a hand-held probe based imaging system. Med Phys. 2008;35(7):3354–3363
  77. Poplack SP, Tosteson AN, Grove MR, Wells WA, Carney PA. Mammography in 53,803 women from the New Hampshire Mammography Network. Radiology. 2000;217:832–840
  78. Venta LA, Dudiak CM, Salomon CG, Flisak ME. Sonographic evaluation of the breast. RadioGraphics. 1994;14:29–50
  79. Rahbar G, Sie AC, Hansen GC, Prince JS, Melany ML, Reynolds HE, et al. Benign versus malignant solid masses: US differentiation. Radiology. 1999;213:889–894
  80. Pogue BW, McBride TO, Osterberg UL, Paulsen KD. Comparison of imaging geometries for diffuse optical tomography of tissue. Opt Express. 1999;4(8):270–286

PII: S1350-4533(08)00179-3

doi: 10.1016/j.medengphy.2008.10.004

Medical Engineering & Physics
Volume 31, Issue 5 , Pages 495-509 , June 2009