Medical Engineering & Physics
Volume 30, Issue 7 , Pages 872-879 , September 2008

Flow analyses in the lower airways: Patient-specific model and boundary conditions

  • J.W. De Backer

      Affiliations

    • University Hospital Antwerp, Department of Pulmonology, Belgium
    • University of Antwerp, Department of Physics, Belgium
    • Corresponding Author InformationCorresponding author at: University Hospital Antwerp, Department of Respiratory Medicine, Wilrijkstraat 10, 2650 Edegem, Belgium. Tel.: +32 475388786; fax: +32 38214447.
  • ,
  • W.G. Vos

      Affiliations

    • University Hospital Antwerp, Department of Pulmonology, Belgium
    • University of Antwerp, Department of Physics, Belgium
  • ,
  • C.D. Gorlé

      Affiliations

    • Von Karman Institute for Fluid Dynamics, Belgium
    • University of Antwerp, EMAT, Belgium
  • ,
  • P. Germonpré

      Affiliations

    • University Hospital Antwerp, Department of Pulmonology, Belgium
  • ,
  • B. Partoens

      Affiliations

    • University of Antwerp, Department of Physics, Belgium
  • ,
  • F.L.Wuyts

      Affiliations

    • University of Antwerp, Department of Physics, Belgium
  • ,
  • P.M. Parizel

      Affiliations

    • University Hospital Antwerp, Department of Radiology, Belgium
  • ,
  • W. De Backer

      Affiliations

    • University Hospital Antwerp, Department of Pulmonology, Belgium

Received 26 March 2007 ,Revised 8 October 2007 ,Accepted 3 November 2007.

References 

  1. Balashazy I, Hofmann W, Martonen TB. Inspiratory particle deposition in airway bifurcation models. J Aerosol Sci. 1991;22:15–30
  2. Boiselle PM. Multislice helical CT of the central airways. Radiol Clin North Am. 2003;41:561–574
  3. Boiselle PM, Dippolito G, Copeland J, Kang H, Ahmed M, Weeks D, et al. Multiplanar and 3D imaging of the central airways: comparison of image quality and radiation dose of single-detector row CT and multi-detector row CT at differing tube currents in dogs. Radiology. 2003;228:107–111
  4. Brown JS, Zeman KL, Bennett WD. Ultrafine particle deposition and clearance in the healthy and obstructed lung. Am J Respir Crit Care Med. 2002;166:1240–1247
  5. Choi LT, Tu JY, Li HF, Thien F. Flow and particle deposition patterns in a realistic human double bifurcation airway model. Inhal Toxicol. 2007;19:117–131
  6. De Backer J, Gorle C, Vanderveken O, Wittesaele W, Oostveen E, Wuyts F, et al. Modelling of upper airway collapse in OSA patients based on computational fluid dynamics. Am J Respir Crit Care Med. 2005;2:
  7. Fetita C, Mancini S, Perchet D, Preteux F, Thiriet M, Vial L. An image-based computational model of oscillatory flow in the proximal part of tracheobronchial trees. Comput Methods Biomech Biomed Eng. 2005;8:279–293
  8. Glor FP, Ariff B, Hughes AD, Crowe LA, Verdonck PR, Barratt DC, et al. Image-based carotid flow reconstruction: a comparison between MRI and ultrasound. Physiol Meas. 2004;25:1495–1509
  9. Hasday JD, McCrea KA, Meltzer SS, Bleeker ER. Dysregulation of airway cytokine expression in chronic obstructive pulmonary disease and asthma. Am J Respir Crit Care Med. 1994;150:S54–S58
  10. Hoffman EA, Simon BA, McLennan G. State of the Art. A structural and functional assessment of the lung via multidetector-row computed tomography: phenotyping chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2006;3(6):519–532In review
  11. Hogg JC. Pathophysiology of airflow limitation in chronic obstructive pulmonary disease. Lancet. 2004;364:709–721
  12. Huang Y, White DP, Malhotra A. Use of computational modeling to predict responses to upper airway surgery in obstructive sleep apnea. Laryngoscope. 2007;117:648–653
  13. Jin HH, Fan JR, Zeng MJ, Cen KF. Large eddy simulation of inhaled particle deposition within the human upper respiratory tract. J Aerosol Sci. 2007;38:257–268
  14. Kleinstreuer C, Zhang Z. Targeted drug aerosol deposition analysis for a four-generation lung airway model with hemispherical tumors. J Biomech Eng. 2003;125:197–206
  15. Li A, Ahmadi G. Computer simulation of particle deposition in the upper tracheobronchal tree. Aerosol Sci Technol. 1995;23:201–223
  16. Lin CL, Tawhai MH, McLennan G, Hoffman EA. Characteristics of the turbulent laryngeal jet and its effect on airflow in the human intra-thoracic airways. Respir Physiol Neurobiol. 2007;157:295–309
  17. Longest PW, Kleinstreuer C, Deanda A. Numerical simulation of wall shear stress and particle-based hemodynamic parameters in pre-cuffed and streamlined end-to-side anastomoses. Ann Biomed Eng. 2005;33:1752–1766
  18. Longest PW, Vinchurkar S. Effects of mesh style and grid convergence on particle deposition in bifurcating airway models with comparisons to experimental data. Med Eng Phys. 2007;29:350–366
  19. Newman SP, Pitcairn GR, Hirst PH. A brief history of gamma scintigraphy. J Aerosol Med. 2001 Summer;14(2):139–145
  20. Nowak N, Kakade PP, Annapragada AV. Computational fluid dynamics simulation of airflow and aerosol deposition in human lungs. Ann Biomed Eng. 2003;31:374–390
  21. Perzl MA, Schultz H, Paretzeke HG, Englmeier KH, Heyder J. Reconstruction of the lung geometry for the simulation of aerosol transport. J Aerosol Med. 1998;9:409–418
  22. Sadowska AM, van Overveld FJ, Gorecka D, Zdral A, Filewska M, Demkow UA, et al. The interrelationship between markers of inflammation and oxidative stress in chronic obstructive pulmonary disease: modulation by inhaled steroids and antioxidant. Respir Med. 2005;99:241–249
  23. Stern F, Wilson RV, Coleman HW, Paterson EG. Comprehensive approach to verification and validation of cfd simulations—Part 1: Methodology and procedures. J Fluids Eng. 2001;123:
  24. Tawhai MH, Nash MP, Hoffman EA. An imaging-based computational approach to model ventilation distribution and soft-tissue deformation in the ovine lung. Acad Radiol. 2006;13:113–120
  25. van Ertbruggen C, Hirsch C, Paiva M. Anatomically based three-dimensional model of airways to simulate flow and particle transport using computational fluid dynamics. J Appl Physiol. 2005;98:970–980
  26. Van Tricht I, De Wachter D, Tordoir J, Verdonck P. Comparison of the hemodynamics in 6mm and 4–7mm hemodialysis grafts by means of CFD. J Biomech. 2006;39:226–236
  27. Vos W, DeBacker J, Devolder A, Vanderveken O, Verhulst S, Salgado R, et al. Correlation between severity of sleep apnea and upper airway morphology based on advanced anatomical and functional imaging. J Biomech. 2007;40(10):2207–2213[Epub 2006 Dec. 18]
  28. Yang XL, Liu Y, Luo HY. Respiratory flow in obstructed airways. J Biomech. 2006;39:2743–2751
  29. Yang XL, Liu Y, So RM, Yang JM. The effect of inlet velocity profile on the bifurcation COPD airway flow. Comput Biol Med. 2006;36:181–194

PII: S1350-4533(07)00184-1

doi: 10.1016/j.medengphy.2007.11.002

Medical Engineering & Physics
Volume 30, Issue 7 , Pages 872-879 , September 2008