Medical Engineering & Physics
Volume 30, Issue 7 , Pages 848-855 , September 2008

Characterization of an alginate-based drug delivery system for neurological applications

  • Gianni Ciofani

      Affiliations

    • CRIM (Center for Research in Microengineering) Lab, Scuola Superiore Sant’Anna, Piazza Martiri della Libertà 33, 56127 Pisa, Italy
    • Corresponding Author InformationCorresponding author at: CRIM (Center for Research in Microengineering), Scuola Superiore Sant’Anna, Viale Rinaldo Piaggio 34, 56025 Pontedera (PI), Italy. Tel.: +39 050883026; fax: +39 050883497.
    • ,
  • Vittoria Raffa

      Affiliations

    • CRIM (Center for Research in Microengineering) Lab, Scuola Superiore Sant’Anna, Piazza Martiri della Libertà 33, 56127 Pisa, Italy
    • ,
  • Tommaso Pizzorusso

      Affiliations

    • Istituto di Neuroscienze, CNR, Via G. Moruzzi 1, 56100 Pisa, Italy
    • ,
  • Arianna Menciassi

      Affiliations

    • CRIM (Center for Research in Microengineering) Lab, Scuola Superiore Sant’Anna, Piazza Martiri della Libertà 33, 56127 Pisa, Italy
    • Italian Institute of Technology (IIT), Via Morego 30, Genova, Italy
    • ,
  • Paolo Dario

      Affiliations

    • CRIM (Center for Research in Microengineering) Lab, Scuola Superiore Sant’Anna, Piazza Martiri della Libertà 33, 56127 Pisa, Italy
    • Italian Institute of Technology (IIT), Via Morego 30, Genova, Italy

Received 6 June 2007 ,Revised 3 October 2007 ,Accepted 16 October 2007.

References 

  1. Maysinger D, Morinville A. Drug delivery to the nervous system. Trends Biotechnol. 1997;15:410–418
  2. Lewin SL, Utley DS, Cheng ET, Verity AN, Terris DJ. Simultaneous treatment with BDNF and CNTF after peripheral nerve transection and repair enhances rate of functional recovery compared with BDNF treatment alone. Laryngoscope. 1997;107:992–999
  3. Santos X, Rodrigo J, Hontanilla B, Bilbao G. Evaluation of peripheral nerve regeneration by nerve growth factor locally administered with a novel system. J Neurosci Meth. 1998;85:119–127
  4. Jones LL, Tuszynski MH. Chronic intrathecal infusions after spinal cord injury cause scarring and compression. Microsc Res Techniq. 2001;317–324
  5. Schmidt CE, Leach LB. Neural tissue engineering: strategies for repair and regeneration. Annu Rev Biomed Eng. 2003;5:293–347
  6. Langer R. Drug delivery and targeting. Nature. 1998;392:5–10
  7. Ciofani G, Raffa V, Menciassi M, Dario P. Alginate and chitosan particles as drug delivery system for cell therapy. Biomed Microdevices. 2008;10:131–140
  8. Gombotz WR, Wee SF. Protein release from alginate matrices. Adv Drug Deliv Rev. 1998;31:267–285
  9. Clark AH, Ross-Murphy SB. Structural and mechanical for the preparation of biopolymer gels. Adv Polym Sci. 1987;83:57–192
  10. Murtas S, Capuani G, Dentini M, Manetti C, Masci G, Massimi M, et al. Alginate beads as immobilization matrix for hepatocytes perfused in a bioreactor: a physico-chemical characterization. J Biomater Sci Polym Ed. 2005;16(7):829–846
  11. Douglas KL, Tabrizian M. Effect of experimental parameters on the formation of alginate–chitosan nanoparticles and evaluation of their potential application as DNA carrier. J Biomater Sci Polym Ed. 2005;16(1):43–56
  12. Wang MS, Childs RF, Chang PL. A novel method to enhance the stability of alginate-poly-l-lysine-alginate microcapsules. J Biomater Sci Polym Ed. 2005;16(1):89–111
  13. Edelman ER, Nugent MA, Karnovsky MJ. Perivascular and intravenous administration of basic fibroblast growth factor: vascular and solid organ deposition. Proc Natl Acad Sci USA. 1993;90:1513–1517
  14. Aisen PS, Marin D, Altstiel L. A pilot study of prednisone in Alzheimer's disease. Dementia. 1996;7:201–206
  15. Mikkelsen A, Eigsaeter A. Density distribution of calcium induces alginate gels: a nemerical study. Biopolymers. 1995;36:17–41
  16. Manz B, Hillgaertner M, Zimmermann H, Zimmermann D, Volke F, Zimmermann U. Cross-linking properties of alginate gels determined by using advanced NMR imaging and Cu2+ as contrast agent. Eur Biophys J. 2004;33:50–58
  17. Stoscheck CM. Quantitation of protein. Method Enzymol. 1990;182:50–69
  18. Brueckner G, Bringmann A, Koeppe G, Haertig W, Brauer K. In vivo and in vitro labelling of perineuronal nets in rat brain. Brain Res. 1996;720:84–92
  19. Øyaas J, Storrø I, Svendsen H, Levine DW. The effective diffusion coefficient and the distribution constant for small molecules in calcium-alginate gel beads. Biotechnol Bioeng. 1995;47(4):492–500
  20. Shively ML, Coonts BA, Renner WD, Southard JL, Bennet AT. Physicochemical characterization of polymeric injectable implant delivery system. J Control Release. 1995;237–243
  21. Huang X, Brazel CS. On the importance and mechanisms of burst release in matrix-controlled drug delivery systems. J Control Release. 2001;73:121–136
  22. Aisen PS. Development of antiinflammatory therapy for Alzheimer's disease. Drug Develop Res. 2002;56:421–427
  23. Batycky RP, Hanes J, Langer R, Edwards DA. A theoretical model of erosion and macromolecular drug release from biodegrading microspheres. J Pharm Sci. 1997;86:1464–1477
  24. Ciofani G, Raffa V, Menciassi M, Micera S, Dario P. A drug delivery system based on alginate microspheres: mass-transport test and in vitro validation. Biomed Microdevices. 2007;9(3):395–403
  25. Polakovic M, Goerner T, Gref R, Dellacherie E. Lidocaine biodegradable nanospheres, modelling of drug release. J Control Release. 1999;60:169–177
  26. Turanyi T, Tomlin AS, Pilling J. On the error of the quasi-steady-state approximation. J Phys Chem. 1993;97:163–172
  27. Suzuki K, Suzuki Y, Tanihara M, Ohnishi K, Hashimoto T, Endo K, et al. Reconstruction of rat peripheral nerve gap without sutures using freeze-dried alginate gel. J Biomed Mater. 2000;49(4):528–533
  28. Derby E, Wayne EV, Frierdich GE, Neises G, Rapp SR, Roua DG. Nerve growth factor facilitates regeneration across nerve gaps: morphological and behavioural studies in rat sciatic nerve. Exp Neurol. 1993;119:176–191
  29. Whittlesey KJ, Shea LD. Delivery systems for small molecule drugs, proteins, and DNA: the neuroscience/biomaterial interface. Exp Neurol. 2004;190:1–16
  30. Ross CJD, Chang PL. Development of small alginate microcapsules for recombinant gene product delivery to the rodent brain. J Biomater Sci Polym Ed. 2002;13(8):953–962
  31. Mak M, Fung L, Strasser JF, Saltzman WM. Distribution of drugs following controlled delivery to the brain interstitium. J Neuro-Oncol. 1995;26(2):91–102
  32. Pizzorusso T, Medini P, Landi S, Baldini S, Berardi N, Maffei L. Structural and functional recovery from early monocular deprivation in adult rats. Proc Natl Acad Sci USA. 2006;103(22):8517–8522

PII: S1350-4533(07)00179-8

doi: 10.1016/j.medengphy.2007.10.003

Medical Engineering & Physics
Volume 30, Issue 7 , Pages 848-855 , September 2008

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