Medical Engineering & Physics
Volume 30, Issue 7 , Pages 843-847 , September 2008

The effect of zoledronic acid on the intrinsic material properties of healing bone: An indentation study

  • Negin Amanat

      Affiliations

    • Orthopaedic Research and Biotechnology, The Children's Hospital at Westmead, Westmead, Australia
    • School of Aerospace, Mechanical and Mechatronic Engineering, University of Sydney, Australia
    • Corresponding Author InformationCorresponding author at: Research Building, Locked Bag 4001, Westmead, NSW 2145, Australia. Tel.: +61 2 98451451; fax: +61 2 98453078.
    • ,
  • Li Hong He

      Affiliations

    • Biomaterials Science Research Unit, Faculty of Dentistry, University of Sydney, Australia
    • ,
  • Michael V. Swain

      Affiliations

    • Biomaterials Science Research Unit, Faculty of Dentistry, University of Sydney, Australia
    • ,
  • David G. Little

      Affiliations

    • Orthopaedic Research and Biotechnology, The Children's Hospital at Westmead, Westmead, Australia
    • Discipline of Paediatrics and Child Health, Faculty of Medicine, University of Sydney, Australia

Received 18 July 2007 ,Revised 28 August 2007 ,Accepted 27 September 2007.

References 

  1. Riggs BL, Parfitt MA. Drugs used to treat osteoporosis: the critical need for a uniform nomenclature based on their action in bone remodelling. J Bone Miner Res. 2005;20:1029–1034
  2. Amanat N, Brown R, Bilston LE, Little DG. A single systemic dose of pamidronate improves bone mineral content and accelerates restoration of strength in a rat model of fracture repair. J Orthop Res. 2005;23:1029–1034
  3. Amanat N, McDonald M, Godfrey C, Bilston LE, Little DG. Optimal timing of a single dose of zoledronic acid to increase strength in rat fracture repair. J Bone Miner Res. 2007;22:867–876
  4. Bilston LE, Little DG, Smith NC, Williams P, Briody J. Zoledronic acid improves the mechanical properties of normal and healing bone. Clin Biomech. 2002;17:716–718
  5. Weber M, Roschger P, Fratzl-Zelman N, Schoberl T, Rauch F, Glorieux FH, et al. Pamidronate does not adversely affect bone intrinsic material properties in children with osteogenesis imperfecta. Bone. 2006;39:616–622
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  9. Rho JY, Tsui TY, Pharr GM. Elastic properties of human cortical and trabecular lamellar bone measured by nanoindentation. Biomaterials. 1997;18:1325–1330
  10. Fleisch H. Can bisphosphonates be given to patients with fractures?. J Bone Miner Res. 2001;16:437–440
  11. Li J, Mori S, Kaji Y, Mashiba T, Kawanishi J, Norimatsu H. Effect of bisphosphonate (incadronate) on fracture healing of long bones in rats. J Bone Miner Res. 1999;14:969–979

PII: S1350-4533(07)00166-X

doi: 10.1016/j.medengphy.2007.09.008

Medical Engineering & Physics
Volume 30, Issue 7 , Pages 843-847 , September 2008

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