Medical Engineering & Physics
Volume 29, Issue 7 , Pages 749-754 , September 2007

Preparation of microbubble suspensions by co-axial electrohydrodynamic atomization

Received 14 June 2006 ,Revised 25 August 2006 ,Accepted 29 August 2006.

References 

  1. Stride E, Saffari N. Microbubble ultrasounsd contrast agents: a review. Proc Mech Eng Part H, J Eng Med. 2003;217:429–447
  2. Unger EC, Matsunaga TO, McCreery T, Schumann P, Sweitzer R, Quigley R. Therapeutic applications of microbubbles. Eur J Radiol. 2002;42:160–168
  3. Bekeredjian R, Grayburn PA, Shohet RV. Use of ultrasound contrast agents for gene or drug delivery in cardiovascular medicine. J Am Coll Cardiol. 2005;45(3):329–335
  4. Yang L, Shirakata Y, Tamai K, Dai X, Hanakawa Y, Tokumaru S, et al. Microbubble-enhanced ultrasound for gene transfer into living skin equivalents. J Dermatol Sci. 2005;40:105–114
  5. Dijkmans PA, Juffermans LJM, Musters RJP, Van Wamel A, Ten Cate FJ, Van Gilst W, et al. Microbubbles and ultrasound: from diagnosis to therapy. Eur J Echocardiogr. 2004;5:245–256
  6. Van Wamel A, Bouakaz A, Bernard B, Ten Cate F, De Jong N. Radionuclide tumour therapy with ultrasound contrast microbubbles. Ultrasonics. 2004;42:903–906
  7. Harvey CJ, Pilcher JM, Eckersley RJ, Blomley MJK, Cosgrove DO. Advances in ultrasound. Clin Radiol. 2002;57(3):157–177
  8. Borden M, Dayton P, Zhao S, Ferrara K. Physico-chemical properties of the microbubble lipid shell. In: Ferroelectrics and frequency control joint 50th anniversary conference, Proceedings of the 2004 IEEE international ultrasonics. 2004;p. 20–23
  9. Unger E, McCreery T, Sweitzer R, Caldwell V, Wu Y. Acoustically active lipospheres containing paclitaxel: a new therapeutic ultrasound contrast agent. Invest Radiol. 1998;33:886–892
  10. Postema M, Bouakaz A, Chin C, De Jong N. Simulations and measurements of optical images of insonified ultrasound contrast microbubbles. IEEE Trans Ultrason Ferroelectr Freq Control. 2003;50:523–535
  11. Jaworek A, Krupa A. Classification of the modes of EHD spraying. J Aerosol Sci. 1999;30:873–893
  12. Tang K, Gomez A. On the structure of an electrostatic spray of monodisperse droplets. Phys Fluids. 1994;6(7):2317–2332
  13. Jayasinghe SN, Edirisinghe MJ. Electrostatic atomisation of a ceramic suspension. J Eur Ceram Soc. 2004;24:2203–2213
  14. Huang J, Jayasinghe SN, Best SM, Edirisinghe MJ, Brooks RA, Bonfield W. Electrospraying of a nano-hydroxyapatite suspension. J Mater Sci. 2004;39:1029–1032
  15. Chen QZ, Boccaccini AR, Zhang HB, Wang DZ, Edirisinghe MJ. Improved mechanical reliability of bone tissue engineering (zirconia) scaffolds by electrospraying. J Am Ceram Soc. 2006;89:1534–1539
  16. Jayasinghe SN, Edirisinghe MJ, De Wilde T. A novel ceramic printing technique based on electrostatic atomization of a suspension. Mater Res Innovations. 2002;6:92–95
  17. Loscertales IG, Barrero A, Guerrero I, Cortijo R, Marquez M, Ganan-Calvo AM. Micro/nano encapsulation via electrified coaxial liquid jets. Science. 2002;295:1695–1698
  18. Balasubramanian K, Jayasinghe SN, Edirisinghe MJ. Coaxial electrohydrodynamic atomization of ceramic suspensions. Int J Appl Ceram Technol. 2006;3:55–60
  19. Pareta R, Edirisinghe MJ. A novel method for the preparation of biodegradable microspheres for protein drug delivery. J R Soc Interface. 2006;3:573–582

PII: S1350-4533(06)00177-9

doi: 10.1016/j.medengphy.2006.08.009

Medical Engineering & Physics
Volume 29, Issue 7 , Pages 749-754 , September 2007