Medical Engineering & Physics
Volume 29, Issue 3 , Pages 350-366 , April 2007

Effects of mesh style and grid convergence on particle deposition in bifurcating airway models with comparisons to experimental data

Received 10 January 2006 ,Revised 11 May 2006 ,Accepted 16 May 2006.

References 

  1. Frederick CB, Bush ML, Lomax LG, Black KA, Finch L, Kimbell JS, et al. Application of a hybrid computational fluid dynamics and physiologically based inhalation model for interspecies dosimetry extrapolation of acidic vapors in the upper airways. Toxicol Appl Pharmacol. 1998;152:211–231
  2. Martonen TB, Musante CJ, Segal RA, Schroeter JD, Hwang D, Dolovich MA, et al. Lung models: strengths and limitations. Respir Care. 2000;45:712–736
  3. Kimbell JS, Overton JH, Subramaniam RP, Schlosser PM, Morgan KT, Conolly RB, et al. Dosimetry modeling of inhaled formaldehyde: binning nasal flux predictions for quantitative risk assessments. Toxicol Sci. 2001;64:111–121
  4. Jarabek AM. The application of dosimetry models to identify key processes and parameters for default dose–response assessment approaches. Toxicol Lett. 1995;79:171–184
  5. Cohen Hubal EA, Fedkiw PS, Kimbell JS. Mass-transport models to predict toxicity of inhaled gases in the upper respiratory tract. J Appl Physiol. 1996;80:1415–1427
  6. Cohen Hubal EA, Kimbell JS, Fedkiw PS. Incorporation of nasal-lining mass-transfer resistance into a CFD model for prediction of ozone dosimetry in the upper respiratory tract. Inhal Toxicol. 1996;8:831–857
  7. Kimbell JS, Subramaniam RP. Use of computational fluid dynamics models for dosimetry of inhaled gases in the nasal passages. Inhal Toxicol. 2001;13:325–334
  8. Martonen TB, Zhang ZQ, Yue G, Musante CJ. Fine particle deposition within human nasal airways. Inhal Toxicol. 2003;15:283–303
  9. Schroeter JD, Musante CJ, Hwang DM, Burton R, Guilmette R, Martonen TB. Hygroscopic growth and deposition of inhaled secondary cigarette smoke in human nasal pathways. Aerosol Sci Technol. 2001;34:137–143
  10. Zhang Z, Kleinstreuer C, Kim CS, Cheng YS. Vaporizing microdroplet inhalation, transport, and deposition in a human upper airway model. Aerosol Sci Technol. 2004;38:36–49
  11. Zhang Z, Kleinstreuer C, Donohue JF, Kim CS. Comparison of micro- and nano-size particle depositions in a human upper airway model. J Aerosol Sci. 2005;36:211–233
  12. Balashazy I, Hofmann W, Heistracher T. Local particle deposition patterns may play a key role in the development of lung cancer. Transl Physiol. 2003;94:1719–1725
  13. Comer JK, Kleinstreuer C, Hyun S, Kim CS. Aerosol transport and deposition in sequentially bifurcating airways. J Biomech Eng. 2000;122:152–158
  14. Heistracher T, Hofmann W. Flow and deposition patterns in successive airway bifurcations. Ann Occup Hygene. 1997;41:537–542
  15. Hofmann W, Golser R, Balashazy I. Inspiratory deposition efficiency of ultrafine particles in a human airway bifurcation model. Aerosol Sci Technol. 2003;37:988–994
  16. Martonen TB, Guan X, Schreck RM. Fluid dynamics in airway bifurcations. I. Primary flows. Inhal Toxicol. 2001;13:261–279
  17. Martonen TB, Guan X, Schreck RM. Fluid dynamics in airway bifurcations. II. Secondary currents. Inhal Toxicol. 2001;13:281–289
  18. Martonen TB, Guan X, Schreck RM. Fluid dynamics in airway bifurcations. III. Localized flow conditions. Inhal Toxicol. 2001;13:291–305
  19. Zhang Z, Kleinstreuer C. Effect of particle inlet distributions on deposition in a triple bifurcation lung airway model. J Aerosol Med: Depos Clearance Effects Lung. 2001;14:13–29
  20. Zhang Z, Kleinstreuer C. Transient airflow structures and particle transport in a sequentially branching lung airway model. Phys Fluids. 2002;14:862–880
  21. Zhang Z, Kleinstreuer C, Kim CS. Effects of asymmetric branch flow rates on aerosol deposition in bifurcating airways. J Med Eng Technol. 2000;24:192–202
  22. Balashazy I, Hofmann W. Deposition of aerosols in asymmetric airway bifurcations. J Aerosol Sci. 1995;26:273–292
  23. Darquenne C. Heterogeneity of aerosol deposition in a two-dimensional model of human alveolated ducts. J Aerosol Sci. 2002;33:1261–1278
  24. Darquenne C, Paiva M. Two- and three dimensional simulations of aerosol transport and deposition in alveolar zone of human lung. J Appl Physiol. 1996;80:1401–1414
  25. Karl A, Henry FS, Tsuda A. Low Reynolds number viscous flow in an alveolated duct. J Biomech Eng: Trans ASME. 2004;126:420–429
  26. DeHaan WH, Finlay WH. Predicting extrathoracic deposition from dry powder inhalers. J Aerosol Sci. 2004;35:309–331
  27. Martonen TB, Katz IM. Deposition patterns of aerosolized drugs within human lungs—effects of ventilatory parameters. Pharmaceut Res. 1993;10:871–878
  28. Martonen TB, Zhang Z, Yue G, Musante CJ. 3-D particle transport within the human upper respiratory tract. J Aerosol Sci. 2002;33:1095–1110
  29. Zhang Z, Kleinstreuer C, Kim CS. Micro-particle transport and deposition in a human oral airway model. J Aerosol Sci. 2002;33:1635–1652
  30. Zhang Z, Kleinstreuer C, Kim CS. Cyclic micron-size particle inhalation and deposition in a triple bifurcation lung airway model. J Aerosol Sci. 2002;33:257–281
  31. Zhang Z, Kleinstreuer C, Kim CS, Hickey AJ. Aerosol transport and deposition in a triple bifurcation bronchial airway model with local tumors. Inhal Toxicol. 2002;14:1111–1133
  32. Martonen TB, Musante CJ. Importance of cloud motion on cigarette smoke deposition in lung airways. Inhal Toxicol. 2000;12:261–280
  33. Zhang Z, Kleinstreuer C. Airflow structures and nano-particle deposition in a human upper airway model. J Comput Phys. 2004;198:178–210
  34. Zhang Z, Martonen TB. Deposition of ultrafine aerosols in human tracheobronchial airways. Inhal Toxicol. 1997;9:99–110
  35. Shi H, Kleinstreuer C, Zhang Z, Kim CS. Nanoparticle transport and deposition in bifurcating tubes with different inlet conditions. Phys Fluids. 2004;16:2199–2213
  36. Katz IM, Davis BM, Martonen TB. A numerical study of particle motion within the human larynx and trachea. J Aerosol Sci. 1999;30:173–183
  37. Martonen TB, Yang Y, Xue ZQ. Effects of carinal ridge shapes on lung airstreams. Aerosol Sci Technol. 1994;21:119–131
  38. Martonen TB, Yang Y, Xue ZQ. Influences of cartilaginous rings on tracheobronchial fluid dynamics. Inhal Toxicol. 1994;6:185–198
  39. Martonen TB, Guan XF. Effects of tumors on inhaled pharmacologic drugs. I. Flow patterns. Cell Biochem Biophys. 2001;35:233–243
  40. Martonen TB, Guan XF. Effects of tumors on inhaled pharmacologic drugs. II. Particle motion. Cell Biochem Biophys. 2001;35:245–253
  41. Comer JK, Kleinstreuer C, Kim CS. Flow structures and particle deposition patterns in double-bifurcation airway models. Part 2. Aerosol transport and deposition. J Fluid Mech. 2001;435:55–80
  42. Zhang Z, Kleinstreuer C, Kim CS. Flow structure and particle transport in a triple bifurcation airway model. J Fluids Eng: Trans ASME. 2001;123:320–330
  43. Balashazy I, Hofmann W. Fluid dynamics and related particle deposition patterns in human airway bifurcations. In:  Martonen TB editors. Medical applications of computer modeling: the respiratory system. Southampton: WIT Press; 2001;p. 83–108
  44. Oldham MJ, Phalen RF, Heistracher T. Computational fluid dynamic predictions and experimental results for particle deposition in an airway model. Aerosol Sci Technol. 2000;32:61–71
  45. Musante CJ, Martonen TB. Computational fluid dynamics in human lungs. I. Effects of natural airway features. In:  Martonen TB editors. Medical applications of computer modeling: the respiratory system. Southampton: WIT Press; 2001;p. 131–146
  46. Ferziger JH, Peric M. Computational methods for fluid dynamics. Berlin: Springer-Verlag; 1999;
  47. Liu YT, Pekkan K, Jones SC, Yoganathan AP. The effects of different mesh generation methods on computational fluid dynamic analysis and power loss assessment in total cavopulmonary connection. J Biomech Eng: Trans ASME. 2004;126:594–603
  48. Prakash S, Ethier CR. Requirements for mesh resolution in 3D computational hemodynamics. J Biomech Eng: Trans ASME. 2001;123:134–144
  49. Tambasco M, Steinman DA. On assessing the quality of particle tracking through computational fluid dynamic models. J Biomech Eng: Trans ASME. 2002;124:166–175
  50. Longest PW, Kleinstreuer C, Buchanan JR. Efficient computation of micro-particle dynamics including wall effects. Comput Fluids. 2004;33:577–601
  51. Comer JK, Kleinstreuer C, Zhang Z. Flow structures and particle deposition patterns in double-bifurcation airway models. Part 1. Air flow fields. J Fluid Mech. 2001;435:25–54
  52. Kim CS, Fisher D. Deposition characteristics of aerosol particles in sequentially bifurcating airway models. Aerosol Sci Technol. 1999;31:198–220
  53. Kim CS. Ultrafine particle deposition in a double bifurcation tube with human G3–G5 airway geometry. Internal Report, U.S. EPA; 2002.
  54. Longest PW, Kleinstreuer C. Comparison of blood particle deposition models for non-parallel flow domains. J Biomech. 2003;36:421–430
  55. Zhao Y, Lieber BB. Steady inspiratory flow in a model symmetrical bifurcation. J Biomech Eng. 1994;116:488–496
  56. Zhao Y, Brunskill CT, Lieber BB. Inspiratory and expiratory steady flow analysis in a model symmetrically bifurcating airway. J Biomech Eng. 1997;119:52–58
  57. Zhao Y, Lieber BB. Steady expiratory flow in a model symmetrical bifurcation. J Biomech Eng. 1994;116:318–323
  58. Heistracher T, Hofmann W. Physiologically realistic models of bronchial airway bifurcations. J Aerosol Sci. 1995;26:497–509
  59. Hammersley JR, Olson DE. Physical models of the smaller pulmonary airways. J Appl Physiol. 1992;72:2402–2414
  60. Horsfield K, Dart G, Olson DE, Filley GF, Cumming G. Models of the human bronchial tree. J Appl Physiol. 1971;31:207–217
  61. ICRP . Human respiratory tract model for radiological protection. New York: Elsevier Science Ltd.; 1994;
  62. Weibel ER. Morphometry of the human lung. Berlin: Springer-Verlag; 1963;
  63. Hofmann W, Martonen TB, Graham RC. Predicted deposition of nonhygroscopic aerosols in the human lung as a function of subject age. J Aerosol Med. 1989;2:49–67
  64. Balashazy I, Hofmann W. Particle deposition in airway bifurcations. I. Inspiratory flow. J Aerosol Sci. 1993;24:745–772
  65. Balashazy I, Hofmann W. Particle deposition in airway bifurcations. II. Experiatory flow. J Aerosol Sci. 1993;24:773–786
  66. Horsfield K, Dart G, Olson DE, Cumming G. Models of the human bronchial tree. J Appl Physiol. 1971;31:207–217
  67. Longest PW, Vinchurkar S. Validating CFD predictions of respiratory aerosol deposition: effects of upstream transition and turbulence. J Biomech, in press.
  68. Daunenhofer JF, Baron JR. Grid adaption for the 2D Eulerian equations. Am Inst Aeronaut Astronaut. 1985;AIAA-85-0484
  69. Morsi SA, Alexander AJ. An investigation of particle trajectories in two-phase flow systems. J Fluid Mech. 1972;55(2):193–208
  70. Hocking LM. The effect of slip on the motion of a sphere close to a wall and of two adjacent spheres. J Eng Math. 1973;7:207–221
  71. Crowe C, Sommerfeld M, Tsuji Y. Multiphase flows with drops and bubbles. Boca Raton: CRC Press; 1998;
  72. Press WH, Teukolsky SA, Vetterling WT, Flannery BP. Numerical recipes in Fortran 77: the art of scientific computing. Cambridge: Cambridge University Press; 1996;
  73. Tannehill JC, Anderson DA, Pletcher RH. Computational fluid mechanics and heat transfer. Washington: Taylor and Francis; 1997;
  74. Rauch RD, Batira JT, Yang NTY. Spatial adaption procedures on unstructured meshes for accurate unsteady aerodynamic flow computations. Technical Report AIAA-91-1106; 1991.
  75. Roache P. Computational fluid dynamics. Albuquerque: Hermosa; 1992;
  76. Longest PW, Kleinstreuer C. Numerical simulation of wall shear stress conditions and platelet localization in realistic end-to-side arterial anastomoses. J Biomech Eng: Trans ASME. 2003;125:671–681
  77. Aftosmis M, Gaitonde D, Tavares TS. On the accuracy, stability, and monotonicity of various reconstruction algorithms for unstructured meshes. In: Proceedings of the 32nd AIAA aerospace sciences meeting, Paper AIAA-94-0415. 1994;
  78. Biswas R, Strawn RC. Tetrahedral and hexahedral mesh adaption for CFD problems. Appl Numer Math. 1998;26:135–151
  79. Lo Iacono G, Tucker PG, Reynolds AM. Predictions for particle deposition from LES of ribbed channel flow. Int J Heat Fluid Flow. 2005;26:558–568
  80. Moulinec C, Benhamadouche S, Laurence D, Peric M. In:  Rodi W editors. LES in a U-bend pipe mesh by polyhedral cells. Elsevier; 2005;p. 237–246
  81. Peric M. Flow simulation using control volumes of arbitrary polyhedral shape. ERCOFTAC Bulletin No. 62; 2004.

PII: S1350-4533(06)00107-X

doi: 10.1016/j.medengphy.2006.05.012

Medical Engineering & Physics
Volume 29, Issue 3 , Pages 350-366 , April 2007

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